FEBS Letters
Volume 579, Issue 8 , Pages 1891-1895, 21 March 2005

When kinases meet mathematics: the systems biology of MAPK signalling

Edited by Robert Russell and Giulio Superti-Furga

  • Walter Kolch

      Affiliations

    • Sir Henry Wellcome Functional Genomics Facility, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK
    • Beatson Institute for Cancer Research, Garscube Estate, Glasgow G61 1BD, UK
    • Corresponding Author InformationCorresponding author. Fax: +44 141 942 6521
    • ,
  • Muffy Calder

      Affiliations

    • Department of Computing Science, University of Glasgow, Glasgow G12 8QQ, UK
    • ,
  • David Gilbert

      Affiliations

    • Department of Computing Science, University of Glasgow, Glasgow G12 8QQ, UK

Accepted 1 February 2005. published online 07 February 2005.

Abstract 

The mitogen activated protein kinase/extracellular signal regulated kinase pathway regulates fundamental cellular function such as cell proliferation, survival, differentiation and motility, raising the question how these diverse functions are specified and coordinated. They are encoded through the activation kinetics of the pathway, a multitude of feedback loops, scaffold proteins, subcellular compartmentalisation, and crosstalk with other pathways. These regulatory motifs alone or in combination can generate a multitude of complex behaviour. Systems biology tries to decode this complexity through mathematical modelling and prediction in order to gain a deeper insight into the inner works of signalling networks.

Keywords: Mitogen activated protein kinase/extracellular signal regulated kinase, Signalling networks, Systems biology, Computational modelling

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 31.50 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Subscribe to this title

    Get unlimited online access to this article and all other articles in this title 24/7 for one year.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.
 

PII: S0014-5793(05)00158-4

doi:10.1016/j.febslet.2005.02.002

FEBS Letters
Volume 579, Issue 8 , Pages 1891-1895, 21 March 2005

Article Tools

* Image Usage & Resolution