FEBS Letters
Volume 514, Issue 1 , Pages 11-16, 6 March 2002

Translocation of tRNA during protein synthesis

Edited by Lev Kisselev

  • Harry F. Noller

      Affiliations

    • Center for Molecular Biology of RNA and Department of Molecular, Cellular and Developmental Biology, Sinsheimer Laboratories, UCSC, Santa Cruz, CA 95064, USA
    • Corresponding Author InformationCorresponding author. Fax: (1)-831-459 3737
    • ,
  • Marat M. Yusupov

      Affiliations

    • Center for Molecular Biology of RNA and Department of Molecular, Cellular and Developmental Biology, Sinsheimer Laboratories, UCSC, Santa Cruz, CA 95064, USA
    • UPR 9004 de Biologie et de Genomiques Structurales du CNRS, IGBMC B.P. 163, 1 rue L. Fries, 67404 Illkirch Cedex – CU de Strasbourg, France.
    • ,
  • Gulnara Z. Yusupova

      Affiliations

    • Center for Molecular Biology of RNA and Department of Molecular, Cellular and Developmental Biology, Sinsheimer Laboratories, UCSC, Santa Cruz, CA 95064, USA
    • UPR 9004 de Biologie et de Genomiques Structurales du CNRS, IGBMC B.P. 163, 1 rue L. Fries, 67404 Illkirch Cedex – CU de Strasbourg, France.
    • ,
  • Albion Baucom

      Affiliations

    • Center for Molecular Biology of RNA and Department of Molecular, Cellular and Developmental Biology, Sinsheimer Laboratories, UCSC, Santa Cruz, CA 95064, USA
    • ,
  • J.H.D. Cate

      Affiliations

    • Center for Molecular Biology of RNA and Department of Molecular, Cellular and Developmental Biology, Sinsheimer Laboratories, UCSC, Santa Cruz, CA 95064, USA
    • Berkeley Center for Structural Biology, Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA

Received 29 November 2001; accepted 2 December 2001.

Abstract 

Coupled translocation of tRNA and mRNA in the ribosome during protein synthesis is one of the most challenging and intriguing problems in the field of translation. We highlight several key questions regarding the mechanism of translocation, and discuss possible mechanistic models in light of the recent crystal structures of the ribosome and its subunits.

Keywords:  Ribosome, Hybrid state, tRNA, mRNA, Translocation, Spirin

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PII: S0014-5793(02)02327-X

FEBS Letters
Volume 514, Issue 1 , Pages 11-16, 6 March 2002

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