FEBS Letters
Volume 514, Issue 1 , Pages 34-36, 6 March 2002

Cysteinyl-tRNA formation and prolyl-tRNA synthetase

Edited by Lev Kisselev

Department of Molecular Biophysics and Biochemistry, Yale University, P.O. Box 208114, 266 Whitney Avenue, New Haven, CT 06520-8114, USA

Received 25 November 2001; received in revised form 10 December 2001; accepted 11 December 2001.

Abstract 

Aminoacyl-tRNA (AA-tRNA) formation is a key step in protein biosynthesis. This reaction is catalyzed with remarkable accuracy by the AA-tRNA synthetases, a family of 20 evolutionarily conserved enzymes. The lack of cysteinyl-tRNA (Cys-tRNA) synthetase in some archaea gave rise to the discovery of the archaeal prolyl-tRNA (Pro-tRNA) synthetase, an enzyme capable of synthesizing Pro-tRNA and Cys-tRNA. Here we review our current knowledge of this fascinating process.

Keywords:  Aminoacyl-tRNA synthetase, Prolyl-tRNA synthetase, Amino acid activation, tRNA, Translation

Abbreviations:  AARS, aminoacyl-tRNA synthetase, Cys-tRNA, cysteinyl-tRNA, Pro-tRNA, prolyl-tRNA, CysRS, cysteinyl-tRNA synthetase, ProRS, prolyl-tRNA synthetase, AA-tRNA, aminoacyl-tRNA

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PII: S0014-5793(02)02331-1

FEBS Letters
Volume 514, Issue 1 , Pages 34-36, 6 March 2002

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