FEBS Letters
Volume 546, Issue 2 , Pages 167-172, 10 July 2003

The diverse spectrum of sliding clamp interacting proteins

Edited by Takashi Gojobori

University of Maryland Biotechnology Institute, Center for Advanced Research in Biotechnology, 9600 Gudelsky Drive, Rockville, MD 20850, USA

Received 28 March 2003; received in revised form 19 May 2003; accepted 20 May 2003.

Abstract 

DNA polymerase sliding clamps are a family of ring-shaped proteins that play essential roles in DNA metabolism. The proteins from the three domains of life, Bacteria, Archaea and Eukarya, as well as those from bacteriophages and viruses, were shown to interact with a large number of cellular factors and to influence their activity. In the last several years a large number of such proteins have been identified and studied. Here the various proteins that have been shown to interact with the sliding clamps of Bacteria, Archaea and Eukarya are summarized.

Keywords:  Cell cycle, DNA repair, DNA replication, Protein–DNA interaction, Protein–protein interaction

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PII: S0014-5793(03)00622-7

doi:10.1016/S0014-5793(03)00622-7

FEBS Letters
Volume 546, Issue 2 , Pages 167-172, 10 July 2003

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