FEBS Letters
Volume 564, Issue 3 , Pages 269-273, 30 April 2004

Heavier-than-air flying machines are impossible

Edited by Fritz Winkler and Andreas Engel

  • L Oliveira

      Affiliations

    • Escola Paulista de Medicina, Sao Paulo, Brazil
    • ,
  • T Hulsen

      Affiliations

    • CMBI, KUN, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands
    • ,
  • D Lutje Hulsik

      Affiliations

    • Molecular Cell Biology, Utrecht University, Utrecht, The Netherlands
    • ,
  • A.C.M Paiva

      Affiliations

    • Escola Paulista de Medicina, Sao Paulo, Brazil
    • ,
  • G Vriend

      Affiliations

    • CMBI, KUN, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands
    • Corresponding Author InformationCorresponding author. Fax: (31)-24-3652977

Received 17 December 2003; accepted 23 February 2004.

Abstract 

Many G protein-coupled receptor (GPCR) models have been built over the years. The release of the structure of bovine rhodopsin in August 2000 enabled us to analyze models built before that period to learn more about the models we build today. We conclude that the GPCR modelling field is riddled with ‘common knowledge’ similar to Lord Kelvin’s remark in 1895 that “heavier-than-air flying machines are impossible”, and we summarize what we think are the (im)possibilities of modelling GPCRs using the coordinates of bovine rhodopsin as a template. Associated WWW pages: http://www.gpcr.org/articles/2003_mod/.

Keywords:  GPCR, Modelling, Bovine rhodopsin, Bacteriorhodopsin, Superposition, Alignment

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 31.50 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Subscribe to this title

    Get unlimited online access to this article and all other articles in this title 24/7 for one year.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.
 

PII: S0014-5793(04)00320-5

doi:10.1016/S0014-5793(04)00320-5

FEBS Letters
Volume 564, Issue 3 , Pages 269-273, 30 April 2004

Article Tools

* Image Usage & Resolution