FEBS Letters
Volume 576, Issue 3 , Pages 408-416 , 22 October 2004

A kunitz-type protease inhibitor bikunin disrupts ligand-induced oligomerization of receptors for transforming growth factor (TGF)-β and subsequently suppresses TGF-β signalings

Edited by Veli-Pekka Lehto

  • Tatsuo Yagyu

      Affiliations

    • NetForce Co. Ltd., Taiko 3-1-18, Nakamura, Nagoya, Aichi 453-0801, Japan
  • ,
  • Hiroshi Kobayashi

      Affiliations

    • Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Handayama 1-20-1, Hamamatsu, Shizuoka 431-3192, Japan
    • Corresponding Author InformationCorresponding author. Fax: +81-53-435-2308
  • ,
  • Kiyoshi Wakahara

      Affiliations

    • NetForce Co. Ltd., Taiko 3-1-18, Nakamura, Nagoya, Aichi 453-0801, Japan
  • ,
  • Hidenori Matsuzaki

      Affiliations

    • NetForce Co. Ltd., Taiko 3-1-18, Nakamura, Nagoya, Aichi 453-0801, Japan
  • ,
  • Toshiharu Kondo

      Affiliations

    • Computer Technology Integration (CTI) Co. Ltd., Meieki-minami 1-27-2, Nakamura, Nagoya, Aichi 450-0003, Japan
  • ,
  • Noriyuki Kurita

      Affiliations

    • Department of Knowledge-Based Information Engineering, Toyohashi University of Technology, Tempaku-cho, Toyohashi 441-8580, Japan
  • ,
  • Hideo Sekino

      Affiliations

    • Department of Knowledge-Based Information Engineering, Toyohashi University of Technology, Tempaku-cho, Toyohashi 441-8580, Japan
  • ,
  • Kiyokazu Inagaki

      Affiliations

    • NetForce Co. Ltd., Taiko 3-1-18, Nakamura, Nagoya, Aichi 453-0801, Japan
  • ,
  • Mika Suzuki

      Affiliations

    • Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Handayama 1-20-1, Hamamatsu, Shizuoka 431-3192, Japan
  • ,
  • Naohiro Kanayama

      Affiliations

    • Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Handayama 1-20-1, Hamamatsu, Shizuoka 431-3192, Japan
  • ,
  • Toshihiko Terao

      Affiliations

    • Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Handayama 1-20-1, Hamamatsu, Shizuoka 431-3192, Japan

Received 21 July 2004 ,Revised 9 August 2004 ,Accepted 14 September 2004.

References 

  1. Salier JP. Trends Biochem. Sci. 1990;15:435–439
  2. Kobayashi H, Gotoh J, Terao T. Eur. J. Cell Biol. 1996;71:380–386
  3. Kobayashi H, Hirashima Y, Sun GW, Fujie M, Nishida T, Takigawa M, et al. J. Biol. Chem. 2000;275:21185–21191
  4. Hirashima Y, Kobayashi H, Suzuki M, Tanaka Y, Kanayama N, Fujie M, et al. J. Biol. Chem. 2001;276:13650–13656
  5. Binette F, Cravens J, Kahoussi B, Haudenschild DR, Goetinck PF. J. Biol. Chem. 1994;269:19116–19122
  6. Kohda D, Morton CJ, Parkar AA, Hatanaka H, Inagaki FM, Campbell ID, et al. Cell. 1996;86:767–775
  7. Kobayashi H, Suzuki M, Sun GW, Hirashima Y, Terao T. Biochim. Biophys. Acta. 2000;1481:310–316
  8. Kobayashi H, Suzuki M, Tanaka Y, Hirashima Y, Terao T. J. Biol. Chem. 2001;276:2015–2022
  9. Aruffo A, Stamenkovic I, Melnick M, Underhill CB, Seed B. Cell. 1990;61:1303–1313
  10. Suzuki M, Kobayashi H, Fujie M, Nishida T, Takigawa M, Kanayama N, et al. J. Biol. Chem. 2002;277:8022–8032
  11. Kobayashi H, Suzuki M, Tanaka Y, Kanayama N, Terao T. J. Biol. Chem. 2003;278:7790–7799
  12. Hirashima Y, Kobayashi H, Suzuki M, Tanaka Y, Kanayama N, Terao T. J. Biol. Chem. 2003;278:26793–26802
  13. Massague J. Annu. Rev. Biochem. 1998;67:753–791
  14. Roberts AB, Sporn MB. Growth Factors. 1993;8:1–9
  15. Piek E, Heldin CH, Ten Dijke P. FASEB J. 1999;13:2105–2124
  16. Suzuki M, Kobayashi H, Tanaka Y, Hirashima Y, Kanayama N, Takei Y, et al. Int. J. Cancer. 2003;104:289–302
  17. Blumenthal SG, Aichele G, Wirth T, Czernilofsky AP, Nordheim A, Dittmer J. J. Biol. Chem. 1999;274:12910–12916
  18. Kobayashi H, Suzuki M, Kanayama N, Nishida T, Takigawa M, Terao T. Eur. J. Biochem. 2002;269:3945–3957
  19. Eickelberg O, Centrella M, Reiss M, Kashgarian M, Wells RG. J. Biol. Chem. 2002;277:823–829
  20. Eickelberg O, Pansky A, Koehler E, Bihl M, Tamm M, Hildebrand P, et al. FASEB J. 2001;15:797–806
  21. Ikedo H, Tamaki K, Ueda S, Kato S, Fujii M, TenDijke P, et al. Int. J. Mol. Med. 2003;11:645–650
  22. Bourguignon LY, Singleton PA, Zhu H, Zhou B. J. Biol. Chem. 2002;277:39703–39712
  23. Ravanti L, Hakkinen L, Larjava H, Saarialho-Kere U, Foschi M, Han J, et al. J. Biol. Chem. 1999;274:37292–37300
  24. Suzuki M, Kobayashi H, Tanaka Y, Hirashima Y, Kanayama N, Takei Y, et al. J. Biol. Chem. 2003;278:14640–14646
  25. Suzuki M, Kobayashi H, Tanaka Y, Hirashima Y, Terao T. Biochim. Biophys. Acta. 2001;1547:26–36
  26. López-Casillas F, Cheifetz S, Doody J, Andres JL, Lane WS, Massagué J. Cell. 1991;67:785–795
  27. Cheifetz S, Andres JL, Massagué J. J. Biol. Chem. 1988;263:16984–16991
  28. Chen C, Wang X-F, Sun L. J. Biol. Chem. 1997;272:12862–12867

PII: S0014-5793(04)01176-7

doi: 10.1016/j.febslet.2004.09.048

FEBS Letters
Volume 576, Issue 3 , Pages 408-416 , 22 October 2004