FEBS Letters
Volume 579, Issue 8 , Pages 1795-1801, 21 March 2005

Study of stem cell function using microarray experiments

Edited by Robert Russell and Giulio Superti-Furga

Ontario Genomics Innovation Centre, Ottawa Health Research Institute, Molecular Medicine Program, 501 Smyth Road, Ottawa, Canada K1H 8L6

Accepted 10 February 2005. published online 23 February 2005.

Abstract 

DNA Microarrays are used to simultaneously measure the levels of thousands of mRNAs in a sample. We illustrate here that a collection of such measurements in different cell types and states is a sound source of functional predictions, provided the microarray experiments are analogous and the cell samples are appropriately diverse. We have used this approach to study stem cells, whose identity and mechanisms of control are not well understood, generating Affymetrix microarray data from more than 200 samples, including stem cells and their derivatives, from human and mouse. The data can be accessed online (StemBase; http://www.scgp.ca:8080/StemBase/).

Keywords: Stem cell, Genomics, Microarray analysis, Microarray database

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PII: S0014-5793(05)00221-8

doi:10.1016/j.febslet.2005.02.020

FEBS Letters
Volume 579, Issue 8 , Pages 1795-1801, 21 March 2005

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