FEBS Letters
Volume 580, Issue 4 , Pages 1094-1102, 13 February 2006

The ABC of auxin transport: The role of p-glycoproteins in plant development

Edited by Ulf-Ingo Flügge

  • Markus Geisler

      Affiliations

    • Zurich-Basel Plant Science Center, Institute of Plant Biology, University of Zurich, CH-8007 Zurich, Switzerland
    • Corresponding Author InformationCorresponding author. Fax: +41 1 634 8204.
    • ,
  • Angus S. Murphy

      Affiliations

    • Department of Horticulture, Purdue University, West Lafayette, IN 47907, USA

Received 31 October 2005; received in revised form 22 November 2005; accepted 22 November 2005. published online 05 December 2005.

Abstract 

A surprising outcome of the Arabidopsis genome project was the annotation of a large number of sequences encoding members of the ABC transporter superfamily, including 22 genes encoding the p-glycoprotein (PGP) subfamily. As mammalian PGP orthologs are associated with multiple drug resistance, plant PGPs were initially presumed to function in detoxification, but were soon seen to have a developmental role. Here, we summarise recent studies of plant PGPs indicating that PGPs mediate the cellular and long-distance transport of the plant hormone auxin. One class of PGPs, represented by AtPGP1, catalyze auxin export, while another class with at least one member, AtPGP4, appears to function in auxin import. Current models on the physiological role of PGPs, their functional interaction and their involvement in cell-to cell (polar) auxin transport are discussed.

Abbreviations: PGP, p-glycoprotein, MDR, multidrug resistance, PAT, polar auxin transport, IAA, indole-3-acetic acid, NPA, 1-N-naphthylphthalamic acid, TWD1, TWISTED DWARF1

Keywords: p-Glycoprotein, ABC transporter, Auxin, Multidrug resistance, Plant development

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PII: S0014-5793(05)01424-9

doi:10.1016/j.febslet.2005.11.054

FEBS Letters
Volume 580, Issue 4 , Pages 1094-1102, 13 February 2006

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