FEBS Letters
Volume 580, Issue 4 , Pages 998-1009, 13 February 2006

The molecular basis of multidrug resistance in cancer: The early years of P-glycoprotein research

Edited by Gerrit van Meer

  • Michael M. Gottesman

      Affiliations

    • Laboratory of Cell Biology, The Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, United States
    • Corresponding Author InformationCorresponding author.
    • ,
  • Victor Ling

      Affiliations

    • BC Cancer Research Center, BC Cancer Agency, Vancouver, BC, Canada V5Z 1L3

Received 2 December 2005; received in revised form 15 December 2005; accepted 16 December 2005. published online 05 January 2006.

Abstract 

The discovery and characterization of P-glycoprotein, an energy-dependent multidrug efflux pump, as a mechanism of multidrug resistance in cancer is generally accepted as a significant contribution to the ongoing effort to end death and suffering from this disease. The historical reflections of Victor Ling and Michael Gottesman concerning the early years of this research highlight the important contributions of the multidisciplinary teams involved in these studies, and illustrate how technological developments in biochemistry and molecular and cell biology enabled this discovery.

Keywords: Multidrug resistance, P-glycoprotein, MDR1, Somatic cell genetics, Transport, Chemotherapy

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PII: S0014-5793(05)01543-7

doi:10.1016/j.febslet.2005.12.060

FEBS Letters
Volume 580, Issue 4 , Pages 998-1009, 13 February 2006

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