FEBS Letters
Volume 580, Issue 4 , Pages 1139-1155, 13 February 2006

Peroxisomal ABC transporters

Edited by Ulf-Ingo Flügge

  • Frederica L. Theodoulou

      Affiliations

    • Crop Performance and Improvement Division, Rothamsted Research, Harpenden, Hertfordshire AL5 2JQ, United Kingdom
    • Corresponding Author InformationCorresponding author. Fax: +44 1582 763010.
    • ,
  • Michael Holdsworth

      Affiliations

    • Division of Agricultural and Environmental Sciences, University of Nottingham Sutton Bonington Campus, Loughborough, Leicestershire LE12 5RD, UK
    • ,
  • Alison Baker

      Affiliations

    • Centre for Plant Sciences, Irene Manton Building, University of Leeds, Leeds LS2 9JT, UK

Received 28 October 2005; received in revised form 22 December 2005; accepted 23 December 2005. published online 05 January 2006.

Abstract 

Peroxisomes perform a range of different functions, dependent upon organism, tissue type, developmental stage or environmental conditions, many of which are connected with lipid metabolism. This review summarises recent research on ATP binding cassette (ABC) transporters of the peroxisomal membrane (ABC subfamily D) and their roles in plants, fungi and animals. Analysis of mutants has revealed that peroxisomal ABC transporters play key roles in specific metabolic and developmental functions in different organisms. A common function is import of substrates for β-oxidation but much remains to be determined concerning transport substrates and mechanisms which appear to differ significantly between phyla.

Keywords: Peroxisome, ABC transporter, β-Oxidation, ALDP, PXA1, CTS

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PII: S0014-5793(06)00007-X

doi:10.1016/j.febslet.2005.12.095

FEBS Letters
Volume 580, Issue 4 , Pages 1139-1155, 13 February 2006

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