Bcr interferes with β-catenin–Tcf1 interaction

Ress, Angelika; Moelling, Karin

doi:10.1016/j.febslet.2006.01.034

« Previous Next »FEBS Letters
Volume 580, Issue 5 , Pages 1227-1230, 20 February 2006

Bcr interferes with β-catenin–Tcf1 interaction

Edited by Lukas Huber

Institute of Medical Virology, University of Zurich, Gloriastrasse 30, CH-8006 Zurich, Switzerland

Received 8 December 2005; received in revised form 5 January 2006; accepted 11 January 2006. published online 18 January 2006.

Abstract

The β-catenin/Tcf complex is a downstream effector of the Wnt signalling pathway. It is a transcription complex, which activates gene expression and contributes to proliferation and tumor progression. Tcf1 in complex with β-catenin is able to activate β-catenin-dependent gene expression. We demonstrate that expressed Bcr is able to bind the transcription factor Tcf1 to disrupt the Tcf1/β-catenin complex. Phosphorylation of Bcr by the tyrosine kinase pp60^src can lead to dissociation of the transcriptionally inactive Bcr/Tcf1 complex. Thus two independent mechanisms may regulate Tcf/β-catenin-mediated transcription via Bcr: binding to β-catenin as we have previously shown and to Tcf1 as shown here.

Keywords: Tcf1, Tcf4, Bcr, β-catenin, pp60^Src, Wnt signalling pathway