FEBS Letters
Volume 580, Issue 5 , Pages 1235-1238, 20 February 2006

Interaction of metallothionein with tumor suppressor p53 protein

Edited by Varda Rotter

  • Elena A. Ostrakhovitch

      Affiliations

    • Department of Pathology, University of Western Ontario, London, Ont., Canada N6A 5C1
    • Corresponding Author InformationCorresponding author. Fax: +1 519 6613370.
    • ,
  • Per-Erik Olsson

      Affiliations

    • Örebro Life Science Center, Department of Natural Science, Örebro University, Örebro, Sweden
    • ,
  • Sean Jiang

      Affiliations

    • Department of Pathology, University of Western Ontario, London, Ont., Canada N6A 5C1
    • ,
  • M. George Cherian

      Affiliations

    • Örebro Life Science Center, Department of Natural Science, Örebro University, Örebro, Sweden

Received 18 October 2005; accepted 12 January 2006. published online 18 January 2006.

Abstract 

Previous reports have shown that metallothionein (MT) may modulate p53 activity through zinc exchange. However, little is known on a direct interaction between MT and p53 in cells. The results demonstrate an interaction between MT and p53 can occur in vitro. The complex between MT and p53 was observed in breast cancer epithelial cells with both wild and inactive type of p53. Furthermore, it was shown that wt-p53 was preferentially associated with Apo-MT. Our data suggest that co-expression of MT and p53 and their complex formation in tumor cells may be involved in regulation of apoptosis in these cells.

Abbreviations: MT, metallothionein, CD, circular dichroism

Keywords: p53, Metallothionein, Protein interaction

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PII: S0014-5793(06)00076-7

doi:10.1016/j.febslet.2006.01.036

FEBS Letters
Volume 580, Issue 5 , Pages 1235-1238, 20 February 2006

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