FEBS Letters
Volume 580, Issue 12 , Pages 2910-2916, 22 May 2006

Oxidized protein degradation and repair in ageing and oxidative stress

Edited by Horst Feldmann

Laboratoire de Biologie et Biochimie Cellulaire du Vieillissement (EA 3106/IFR 117), Université Denis Diderot, Paris 7, 2 Place Jussieu, 75005 Paris, France

Received 1 March 2006; accepted 6 March 2006. published online 16 March 2006.

Abstract 

Cellular ageing is characterized by the accumulation of oxidatively modified proteins which may be due to increased protein damage and/or decreased elimination of oxidized protein. Since the proteasome is in charge of protein turnover and removal of oxidized protein, its fate during ageing and upon oxidative stress has received special attention, and evidence has been provided for an age-related impairment of proteasome function. However, proteins when oxidized at the level of sulfur-containing amino acids can also be repaired. Therefore, the fate of the methionine sulfoxide reductase system during ageing has also been addressed as well as its role in protection against oxidative stress.

Keywords: Oxidized protein, Ageing, Oxidative stress, Proteasome, Lon protease, Methionine sulfoxide reductase

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PII: S0014-5793(06)00330-9

doi:10.1016/j.febslet.2006.03.028

FEBS Letters
Volume 580, Issue 12 , Pages 2910-2916, 22 May 2006

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