FEBS Letters
Volume 580, Issue 9 , Pages 2166-2169, 17 April 2006

Cytochrome c6A is a funnel for thiol oxidation in the thylakoid lumen

Edited by Richard Cogdell

  • Beatrix G. Schlarb-Ridley

      Affiliations

    • Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, UK
    • ,
  • Robert H. Nimmo

      Affiliations

    • Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, UK
    • ,
  • Saul Purton

      Affiliations

    • Department of Biology, University College London, London WC1E 6BT, United Kingdom
    • ,
  • Christopher J. Howe

      Affiliations

    • Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, UK
    • Corresponding Author InformationCorresponding author. Fax: +44 1223 333345.
    • ,
  • Derek S. Bendall

      Affiliations

    • Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, UK

Received 2 March 2006; received in revised form 17 March 2006; accepted 20 March 2006. published online 27 March 2006.

Abstract 

Cytochrome c6A is a dithio-cytochrome recently discovered in land plants and green algae, and believed to be derived from the well-known cytochrome c6. The function of cytochrome c6A is unclear. We propose that it catalyses the formation of disulphide bridges in thylakoid lumen proteins in a single-step disulphide exchange reaction, with subsequent transfer of the reducing equivalents to plastocyanin. The haem group of cytochrome c6A acts as an electron sink, allowing rapid resolution of a radical intermediate formed during reoxidation of cytochrome c6A. Our model is consistent with previously published data on mutant plants, and the likely evolution of the protein.

Keywords: Plastocyanin, Disulphide exchange, Cytochrome c6A, Disulphide formation, Thylakoid, Photosystem

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PII: S0014-5793(06)00367-X

doi:10.1016/j.febslet.2006.03.052

FEBS Letters
Volume 580, Issue 9 , Pages 2166-2169, 17 April 2006

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