FEBS Letters
Volume 580, Issue 12 , Pages 2850-2852, 22 May 2006

Potassium channels as tumour markers

Edited by Horst Feldmann

  • Walter Stühmer

      Affiliations

    • Max-Planck Institute for Experimental Medicine, Hermann-Rein-Strasse 3, 37075 Göttingen, Germany
    • Corresponding Author InformationCorresponding author. Fax: +49 551 3899 644.
    • ,
  • Frauke Alves

      Affiliations

    • Department of Hematology and Oncology, University of Göttingen, Robert-Koch-Strasse 40, 37075 Göttingen, Germany
    • ,
  • Franziska Hartung

      Affiliations

    • Max-Planck Institute for Experimental Medicine, Hermann-Rein-Strasse 3, 37075 Göttingen, Germany
    • ,
  • Marta Zientkowska

      Affiliations

    • Department of Hematology and Oncology, University of Göttingen, Robert-Koch-Strasse 40, 37075 Göttingen, Germany
    • ,
  • Luis A. Pardo

      Affiliations

    • Max-Planck Institute for Experimental Medicine, Hermann-Rein-Strasse 3, 37075 Göttingen, Germany

Received 1 March 2006; received in revised form 13 March 2006; accepted 22 March 2006. published online 31 March 2006.

Abstract 

An increasing number of ion channels are being found to be causally involved in diseases, giving rise to the new field of “channelopathies”. Cancer is no exception, and several ion channels have been linked to tumour progression. Among them is the potassium channel EAG (Ether-a-go-go). Over 75% of tumours have been tested positive using a monoclonal antibody specific for EAG, while inhibition of this channel decreased the proliferation of EAG expressing cells. The inhibition of EAG is accomplished using RNA interference, functional anti-EAG1 antibodies, or (unspecific) EAG channel blockers. Fluorescently labelled recombinant Fab fragments recognizing EAG allow the distribution of EAG to be visualized in an in vivo mouse tumour model.

Keywords: EAG, Cancer, Ion channels, Oncogene, Near-infrared imaging

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 31.50 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Subscribe to this title

    Get unlimited online access to this article and all other articles in this title 24/7 for one year.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.
 

PII: S0014-5793(06)00378-4

doi:10.1016/j.febslet.2006.03.062

FEBS Letters
Volume 580, Issue 12 , Pages 2850-2852, 22 May 2006

Article Tools

* Image Usage & Resolution