FEBS Letters
Volume 580, Issue 12 , Pages 2853-2859, 22 May 2006

Cyclic nucleotide-gated ion channels in sensory transduction

Edited by Horst Feldmann

International School for Advanced Studies, S.I.S.S.A., Sector of Neurobiology, Via Beirut 2-4, 34014 Trieste, Italy

Received 26 March 2006; accepted 31 March 2006. published online 13 April 2006.

Abstract 

Cyclic nucleotide-gated (CNG) channels, directly activated by the binding of cyclic nucleotides, were first discovered in retinal rods, cones and olfactory sensory neurons. In the visual and olfactory systems, CNG channels mediate sensory transduction by conducting cationic currents carried primarily by sodium and calcium ions. In olfactory transduction, calcium in combination with calmodulin exerts a negative feedback on CNG channels that is the main molecular mechanism responsible for fast adaptation in olfactory sensory neurons. Six mammalian CNG channel genes are known and some human visual disorders are caused by mutations in retinal rod or cone CNG genes.

Abbreviation: CNG, cyclic nucleotide-gated

Keywords: Transduction, Sensory, Adaptation, Olfaction, cAMP, Channelopathy

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PII: S0014-5793(06)00414-5

doi:10.1016/j.febslet.2006.03.086

FEBS Letters
Volume 580, Issue 12 , Pages 2853-2859, 22 May 2006

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