FEBS Letters
Volume 580, Issue 12 , Pages 2879-2887, 22 May 2006

Biology of vascular endothelial growth factors

Edited by Horst Feldmann

  • Himadri Roy

      Affiliations

    • Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Kuopio, P.O. Box 1627, FIN-70211, Kuopio, Finland
    • ,
  • Shalini Bhardwaj

      Affiliations

    • Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Kuopio, P.O. Box 1627, FIN-70211, Kuopio, Finland
    • ,
  • Seppo Ylä-Herttuala

      Affiliations

    • Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Kuopio, P.O. Box 1627, FIN-70211, Kuopio, Finland
    • Department of Medicine University of Kuopio, FIN-70211, Finland
    • Gene Therapy Unit, Kuopio University Hospital, FIN-70210, Finland
    • Corresponding Author InformationCorresponding author. Fax: +358 17 163751.

Received 14 February 2006; received in revised form 27 March 2006; accepted 31 March 2006. published online 17 April 2006.

Abstract 

Angiogenesis is the process by which new blood vessels are formed from existing vessels. The vascular endothelial growth factors (VEGFs) are considered as key molecules in the process of angiogenesis. The VEGF family currently includes VEGF-A, -B, -C, -D, -E, -F and placenta growth factor (PlGF), that bind in a distinct pattern to three structurally related receptor tyrosine kinases, denoted VEGF receptor-1, -2, and -3. VEGF-C and VEGF-D also play a crucial role in the process of lymphangiogenesis. Here, we review the biology of VEGFs and evaluate their role in pathological angiogenesis and lymphangiogenesis.

Keywords: VEGF, Angiogenesis, Signaling, Diseases

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PII: S0014-5793(06)00415-7

doi:10.1016/j.febslet.2006.03.087

FEBS Letters
Volume 580, Issue 12 , Pages 2879-2887, 22 May 2006

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