FEBS Letters
Volume 580, Issue 11 , Pages 2531-2533, 15 May 2006

Engrailed: Complexity and economy of a multi-functional transcription factor

Edited by Ivan Sadowski

  • Richard Morgan

      Affiliations

    • Corresponding Author InformationAddress: Postgraduate Medical School, University of Surrey, Daphne Jackson Road, Guildford GU2 7WG, United Kingdom. Fax: +44 1483 688558.

Postgraduate Medical School, University of Surrey, Guildford, Surrey GU2 7XH, UK

Received 14 February 2006; received in revised form 12 April 2006; accepted 17 April 2006. published online 27 April 2006.

Abstract 

Engrailed is a homeodomain-containing transcription factor with numerous, overlapping roles in neural development. Its multifunctional nature depends upon an extremely diverse group of molecular functions including the ability to regulate both transcription and translation, and to be released from and internalized by cells. Recent findings have shown how some of these functions relate to specific roles in development and disease.

Keywords: Engrailed, Transcription, Development, Neural, Cancer

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PII: S0014-5793(06)00493-5

doi:10.1016/j.febslet.2006.04.053

FEBS Letters
Volume 580, Issue 11 , Pages 2531-2533, 15 May 2006

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