FEBS Letters
Volume 580, Issue 23 , Pages 5484-5491, 9 October 2006

A proposed model of fat packaging by exchangeable lipid droplet proteins

Edited by Gerrit van Meer

  • Nathan E. Wolins

      Affiliations

    • Department of Medicine, Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, Saint Louis, MO 63110, United States
    • ,
  • Dawn L. Brasaemle

      Affiliations

    • Department of Nutritional Sciences, Rutgers, The State University of New Jersey, New Brunswick, NJ 08901, United States
    • ,
  • Perry E. Bickel

      Affiliations

    • Department of Medicine, Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, Saint Louis, MO 63110, United States
    • Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, MO 63110, United States
    • Corresponding Author InformationCorresponding author. Present address: Departments of Medicine and of Cell Biology and Physiology, 660 S. Euclid Avenue, Campus Box 8127, Saint Louis, MO 63110, United States. Fax: +1 314 362 7641.

Received 24 July 2006; received in revised form 22 August 2006; accepted 22 August 2006. published online 01 September 2006.

Abstract 

Humans have evolved mechanisms of efficient fat storage to survive famine, but these mechanisms contribute to obesity in our current environment of plentiful food and reduced activity. Little is known about how animals package fat within cells. Five related structural proteins serve roles in packaging fat into lipid droplets. The proteins TIP47, S3–12, and OXPAT/MLDP/PAT-1 move from the cytosol to coat nascent lipid droplets during rapid fat storage. In contrast, perilipin and adipophilin constitutively associate with lipid droplets and play roles in sustained fat storage and regulation of lipolysis. Different tissues express different complements of these lipid droplet proteins. Thus, the tissue-specific complement of these proteins determines how tissues manage lipid stores.

Keywords: Lipid droplet, PAT proteins, Triacylglycerol, S3–12, TIP47, Perilipin, ADRP, Adipophilin, OXPAT, MLDP, PAT-1

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PII: S0014-5793(06)01016-7

doi:10.1016/j.febslet.2006.08.040

FEBS Letters
Volume 580, Issue 23 , Pages 5484-5491, 9 October 2006

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