FEBS Letters
Volume 580, Issue 23 , Pages 5467-5476, 9 October 2006

Sphingolipids in cancer: Regulation of pathogenesis and therapy

Edited by Bernd Helms

Department of Biochemistry and Molecular Biology, Hollings Cancer Center, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA

Received 8 July 2006; received in revised form 10 August 2006; accepted 14 August 2006. published online 04 September 2006.

Abstract 

Sphingolipids are known to play important roles in the regulation of cell proliferation, response to chemotherapeutic agents, and/or prevention of cancer. Recently, significant progress has been made in the identification of the enzymes and their biochemical functions involved in sphingolipid metabolism. In addition, development of new techniques for the quantitative analysis of sphingolipids at their physiological levels has facilitated studies to examine distinct functions of these bioactive sphingolipids in cancer pathogenesis and therapy. This review will focus on the recent developments regarding the roles of bioactive sphingolipids in the regulation of cell growth/proliferation, and anti-cancer therapeutics.

Keywords: Sphingolipid, Ceramide, Sphingosine, Cancer, Pathogenesis, Chemotherapy, Drug resistance, Chemoprevention

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PII: S0014-5793(06)01041-6

doi:10.1016/j.febslet.2006.08.052

FEBS Letters
Volume 580, Issue 23 , Pages 5467-5476, 9 October 2006

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