Circulating (cell-free) nucleic acids – A promising, non-invasive tool for early detection of several human diseases

Edited by Veli-Pekka Lehto

Received 25 September 2006; received in revised form 21 December 2006; accepted 22 January 2007. published online 01 February 2007.

Abstract

Circulating nucleic acids (CNA) are present in small amounts in the plasma of healthy individuals. However, increased levels of plasma CNA have been reported in a number of clinical disorders like cancer, stroke, trauma, myocardial infarction, autoimmune disorders, and pregnancy-associated complications. CNA has received special attention because of its potential application as a non-invasive, rapid and sensitive tool for molecular diagnosis and monitoring of acute pathologies and the prenatal diagnosis of fetal genetic diseases. This review throws light on the current status of blood CNA as a diagnostic marker and its potential as a powerful tool in the future.

Abbreviations: CNA, circulating nucleic acid, MI, myocardial infraction, SSc, systemic sclerosis, SCLC, small cell lung carcinoma, SLE, systemic lupus erythematosus, MSP, methylation specific PCR, NPC, nasopharyngeal carcinoma

Keywords: Circulating nucleic acids, Cell-free nucleic acid, Plasma DNA

Department of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110 029, India

Corresponding author. Fax: +91 11 268588641/26588663/26584794.

PII: S0014-5793(07)00094-4

doi:10.1016/j.febslet.2007.01.051

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