FEBS Letters
Volume 581, Issue 5 , Pages 1067-1070, 6 March 2007

Carnosine and its constituents inhibit glycation of low-density lipoproteins that promotes foam cell formation in vitro

Edited by Sandro Sonnino

  • Imran Rashid

      Affiliations

    • Free Radical Group, Heart Research Institute, Sydney, NSW 2050, Australia
    • ,
  • David M. van Reyk

      Affiliations

    • Department of Medical and Molecular Biosciences, University of Technology, Sydney, NSW 2007, Australia
    • Corresponding Author InformationCorresponding author. Fax: +61 2 9514 8206.
    • ,
  • Michael J. Davies

      Affiliations

    • Free Radical Group, Heart Research Institute, Sydney, NSW 2050, Australia
    • Faculty of Medicine, University of Sydney, NSW 2006, Australia

Received 13 December 2006; received in revised form 23 January 2007; accepted 25 January 2007. published online 07 February 2007.

Abstract 

Glycation of low-density lipoprotein (LDL) by reactive aldehydes, such as glycolaldehyde, can result in the cellular accumulation of cholesterol in macrophages. In this study, it is shown that carnosine, or its constituent amino acids β-alanine and l-histidine, can inhibit the modification of LDL by glycolaldehyde when present at equimolar concentrations to the modifying agent. This protective effect was accompanied by inhibition of cholesterol and cholesteryl ester accumulation in human monocyte-derived macrophages incubated with the glycated LDL. Thus, carnosine and its constituent amino acids may have therapeutic potential in preventing diabetes-induced atherosclerosis.

Abbreviations: AGE, advanced glycation end products, β-Ala, β-alanine, CN, carnosine, GA, glycolaldehyde, His, histidine, HMDM, human monocyte-derived macrophages, REM, relative electrophoretic mobility

Keywords: Atherosclerosis, Aldehyde, Carnosine, Foam cell, Glycation, Low-density lipoprotein

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PII: S0014-5793(07)00130-5

doi:10.1016/j.febslet.2007.01.082

FEBS Letters
Volume 581, Issue 5 , Pages 1067-1070, 6 March 2007

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