FEBS Letters
Volume 581, Issue 11 , Pages 2125-2130, 22 May 2007

Rab cascades and tethering factors in the endomembrane system

Edited by Thomas Söllner

University of Osnabrück, Department of Biology, Biochemistry Section, Barbarastrasse 13, 49076 Osnabrück, Germany

Received 15 December 2006; received in revised form 22 January 2007; accepted 30 January 2007. published online 12 February 2007.

Abstract 

Rab GTPases are key proteins that determine organelle identity and operate at the center of fusion reactions. Like Ras, they act as switches that are connected to a diverse network of tethering factors, exchange factors and GTPase activating proteins. Recent studies suggest that Rabs are linked to each other via their effectors, thus coordinating protein transport in the endomembrane system. Within this review, we will focus on selected examples that highlight these issues.

Keywords: Rab GTPases, Tethering factor, Rab effector, Vesicular transport, Endomembrane, Rab cascade

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PII: S0014-5793(07)00145-7

doi:10.1016/j.febslet.2007.01.090

FEBS Letters
Volume 581, Issue 11 , Pages 2125-2130, 22 May 2007

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