Regulating cytoskeleton-based vesicle motility

Abstract 

During vesicular transport, the assembly of the coat complexes and the selection of cargo proteins must be coordinated with the subsequent translocation of vesicles from the donor to an acceptor compartment. Here, we review recent progress toward uncovering the molecular mechanisms that connect transport vesicles to the protein machinery responsible for cytoskeleton-mediated motility. An emerging theme is that vesicle cargo proteins, either directly or through binding interactions with coat proteins, are able to influence cytoskeletal dynamics and motor protein function. Hence, a vesicle’s cargo composition may help direct its intracellular motility and targeting.

Abbreviations: COPI, coat-protomer I, TIRF, total internal reflection fluorescence, Hip, huntingtin interacting protein, low-density lipoprotein, EGF, epidermal growth factor, ERM, ezrin/radixin/moesin, ER, endoplasmic reticulum, ERGIC, ER/Golgi intermediate compartment

Keywords: Vesicular transport, Actin, Microtubules, Dynein, Kinesin, Myosin