Carbon inhibits vascular endothelial growth factor- and fibroblast growth factor-promoted angiogenesis

Murugesan, Saravanababu; Mousa, Shaker A.; O’Connor, Laura J.; Lincoln, David W.; Linhardt, Robert J.

doi:10.1016/j.febslet.2007.02.022

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Volume 581, Issue 6 , Pages 1157-1160, 20 March 2007

Carbon inhibits vascular endothelial growth factor- and fibroblast growth factor-promoted angiogenesis

Edited by Veli-Pekka Lehto

Saravanababu Murugesan
- Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, 110, 8th Street, Troy, NY 12180, USA
- Department of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute, 110, 8th Street, Troy, NY 12180, USA
- Department of Biology, Rensselaer Polytechnic Institute, 110, 8th Street, Troy, NY 12180, USA
Shaker A. Mousa
- Pharmaceutical Research Institute, Albany College of Pharmacy, Albany, NY 12208, USA
Laura J. O’Connor
- Pharmaceutical Research Institute, Albany College of Pharmacy, Albany, NY 12208, USA
David W. Lincoln II
- Pharmaceutical Research Institute, Albany College of Pharmacy, Albany, NY 12208, USA
Robert J. Linhardt
- Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, 110, 8th Street, Troy, NY 12180, USA
- Department of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute, 110, 8th Street, Troy, NY 12180, USA
- Department of Biology, Rensselaer Polytechnic Institute, 110, 8th Street, Troy, NY 12180, USA
- Pharmaceutical Research Institute, Albany College of Pharmacy, Albany, NY 12208, USA
- Corresponding author. Fax: +1 518 276 3405.

Received 21 December 2006; accepted 12 February 2007. published online 20 February 2007.

Abstract

Angiogenesis is important for normal growth and wound healing processes. An imbalance of the growth factors involved in this process, however, causes the acceleration of several diseases including malignant, ocular, and inflammatory diseases. Inhibiting angiogenesis through interfering with its pathway is a promising methodology to hinder the progression of these diseases. Herein, we studied the anti-angiogenic effects of various carbon materials such as graphite, multiwalled carbon nanotubes and fullerenes in vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (FGF2)-induced angiogenesis evaluated in the chick chorioallantoic membrane (CAM) model. All the carbon materials tested showed substantial anti-angiogenic activity against either FGF2- or VEGF-induced angiogenesis in the CAM model. Those carbon materials did not have any significant effects on basal angiogenesis in the absence of the added growth factors.

Keywords: Nanotubes, Fullerenes, Carbon, Anti-angiogenic, CAM assay