Gene expression of cyclin-dependent kinase subunit Cks2 is repressed by the tumor suppressor p53 but not by the related proteins p63 or p73

Rother, Karen; Dengl, Markus; Lorenz, Jana; Tschöp, Katrin; Kirschner, Ralf; Mössner, Joachim; Engeland, Kurt

doi:10.1016/j.febslet.2007.02.028

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Volume 581, Issue 6 , Pages 1166-1172, 20 March 2007

Gene expression of cyclin-dependent kinase subunit Cks2 is repressed by the tumor suppressor p53 but not by the related proteins p63 or p73

Edited by Varda Rotter

Karen Rother
- Medizinische Klinik II, Max-Bürger-Forschungszentrum, Universität Leipzig, Johannisallee 30, D-04103 Leipzig, Germany
- Interdisziplinäres Zentrum für Klinische Forschung (IZKF) Leipzig, Max-Bürger-Forschungszentrum, Universität Leipzig, Johannisallee 30, D-04103 Leipzig, Germany
Markus Dengl
- Medizinische Klinik II, Max-Bürger-Forschungszentrum, Universität Leipzig, Johannisallee 30, D-04103 Leipzig, Germany
Jana Lorenz
- Medizinische Klinik II, Max-Bürger-Forschungszentrum, Universität Leipzig, Johannisallee 30, D-04103 Leipzig, Germany
Katrin Tschöp
- Medizinische Klinik II, Max-Bürger-Forschungszentrum, Universität Leipzig, Johannisallee 30, D-04103 Leipzig, Germany
Ralf Kirschner
- Medizinische Klinik II, Max-Bürger-Forschungszentrum, Universität Leipzig, Johannisallee 30, D-04103 Leipzig, Germany
- Interdisziplinäres Zentrum für Klinische Forschung (IZKF) Leipzig, Max-Bürger-Forschungszentrum, Universität Leipzig, Johannisallee 30, D-04103 Leipzig, Germany
Joachim Mössner
- Medizinische Klinik II, Max-Bürger-Forschungszentrum, Universität Leipzig, Johannisallee 30, D-04103 Leipzig, Germany
Kurt Engeland
- Medizinische Klinik II, Max-Bürger-Forschungszentrum, Universität Leipzig, Johannisallee 30, D-04103 Leipzig, Germany
- Corresponding author. Fax: +49 341 9712209.

Received 17 November 2006; received in revised form 12 February 2007; accepted 13 February 2007. published online 28 February 2007.

Abstract

Cks2 proteins are essential components of cyclin/cyclin-dependent kinase complexes and contribute to cell cycle control. We identify Cks2 as a transcriptional target downregulated by the tumor suppressor p53. Cks2 expression was found to be repressed by p53 both at the mRNA and the protein levels. p53 downregulates transcription from the Cks2 promoter in a dose-dependent manner and in all cell types tested. This repression appears to be independent of p53 binding to the Cks2 promoter. In contrast to p53, neither p63 nor p73 proteins can repress Cks2 transcription. Thus p53, rather than its homologues p63 and p73, may contribute to control of the first metaphase/anaphase transition of mammalian meiosis by downregulation of Cks2 expression.

Keywords: Cks2, Tumor suppressor p53, p63, p73, Cyclin-dependent kinase subunit 2, Transcriptional repression