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Volume 581, Issue 6, Pages 1227-1232 (20 March 2007)


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CD36 is a receptor for oxidized high density lipoprotein: Implications for the development of atherosclerosis

Edited by Richard Marais

Rick F. ThorneacCorresponding Author Informationemail address, Nizar M. Mhaidatbc, Kylie J. Ralstonac, Gordon F. Burnsac

Received 3 January 2007; received in revised form 8 February 2007; accepted 12 February 2007. published online 01 March 2007.

Abstract 

Atherosclerotic plaques result from the excessive deposition of cholesterol esters derived from lipoproteins and lipoprotein fragments. Tissue macrophage within the intimal space of major arterial vessels have been shown to play an important role in this process. We demonstrate in a transfection system using two human cell lines that the macrophage scavenger receptor CD36 selectively elicited lipid uptake from Cu2+-oxidized high density lipoprotein (HDL) but not from native HDL or low density lipoprotein (LDL). The uptake of oxHDL displayed morphological and biochemical similarities with the CD36-dependent uptake of oxidized LDL. CD36-mediated uptake of oxidized HDL by macrophage may therefore contribute to atheroma formation.

a Cancer Research Unit, School of Biomedical Science, Faculty of Health, The University of Newcastle, NSW 2308, Australia

b Immunology and Oncology Unit, Newcastle Misericordiae Hospital, NSW 2310, Australia

c Hunter Medical Research Institute, Australia

Corresponding Author InformationCorresponding author. Fax: +61 2 49216903.

PII: S0014-5793(07)00209-8

doi:10.1016/j.febslet.2007.02.043


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