FEBS Letters
Volume 581, Issue 8 , Pages 1631-1634, 17 April 2007

Hepatic stellate cell damage may lead to decreased plasma ADAMTS13 activity in rats

Edited by Beat Imhof

  • Yukio Kume

      Affiliations

    • Department of Laboratory Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
    • ,
  • Hitoshi Ikeda

      Affiliations

    • Department of Laboratory Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
    • Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
    • Corresponding Author InformationCorresponding author. Address: Department of Laboratory Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. Fax: +81 3 5689 0495.
    • ,
  • Morihiro Inoue

      Affiliations

    • Department of Laboratory Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
    • ,
  • Kazuaki Tejima

      Affiliations

    • Department of Laboratory Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
    • Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
    • ,
  • Tomoaki Tomiya

      Affiliations

    • Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
    • ,
  • Takako Nishikawa

      Affiliations

    • Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
    • ,
  • Naoko Watanabe

      Affiliations

    • Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
    • ,
  • Tatsuya Ichikawa

      Affiliations

    • Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
    • ,
  • Makoto Kaneko

      Affiliations

    • Department of Laboratory Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
    • ,
  • Shigeo Okubo

      Affiliations

    • Department of Laboratory Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
    • ,
  • Hiromitsu Yokota

      Affiliations

    • Department of Laboratory Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
    • ,
  • Masao Omata

      Affiliations

    • Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
    • ,
  • Kenji Fujiwara

      Affiliations

    • Yokohama Rohsai Hospital, 3211 Kodukue-chou, Koh-hoku-ku, Yokohama, Kanagawa 222-0036, Japan
    • ,
  • Yutaka Yatomi

      Affiliations

    • Department of Laboratory Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan

Received 13 February 2007; received in revised form 2 March 2007; accepted 9 March 2007. published online 22 March 2007.

Abstract 

ADAMTS13 is gaining attention, because its deficiency causes thrombotic thrombocytopenic purpura. Although its regulatory mechanism is not fully understood, we wondered if hepatic stellate cells (HSCs) play a role, because ADAMTS13 mRNA is exclusively expressed in the liver and primarily in HSCs. Plasma ADAMTS13 activity was markedly reduced in dimethylnitrosamine-treated rats, where HSC apoptosis is an essential event, but not in carbon tetrachloride- or thioacetamide-treated rats without HSC apoptosis. Furthermore, plasma ADAMTS13 activity was also reduced in 70% hepatectomized rats, where HSC loss occurs. These results suggest that HSC may be involved in the regulation of plasma ADAMTS13 activity.

Keywords: ADAMTS13, Hepatic stellate cell, Dimethylnitrosamine, Hepatectomy

 

PII: S0014-5793(07)00289-X

doi:10.1016/j.febslet.2007.03.029

FEBS Letters
Volume 581, Issue 8 , Pages 1631-1634, 17 April 2007

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