FEBS Letters
Volume 581, Issue 19 , Pages 3608-3615, 31 July 2007

The aryl hydrocarbon receptor, more than a xenobiotic-interacting protein

Edited by Robert Barouki

  • Robert Barouki

      Affiliations

    • INSERM, UMR-S 747, 75270 Paris Cedex 06, France
    • Université René Descartes Paris 5, 45 Rue des Saints-Pères, 75270 Paris Cedex 06, France
    • Fax: +33 1 42863368.
    • ,
  • Xavier Coumoul

      Affiliations

    • INSERM, UMR-S 747, 75270 Paris Cedex 06, France
    • Université René Descartes Paris 5, 45 Rue des Saints-Pères, 75270 Paris Cedex 06, France
    • Fax: +33 1 42863368.
    • ,
  • Pedro M. Fernandez-Salguero

      Affiliations

    • Departamento de Bioquímica y Biología Molecular, Facultad de Ciencias, Universidad de Extremadura, Avda. de Elvas s/n, 06080 Badajoz, Spain
    • Corresponding Author InformationCorresponding author. Fax: +34 924 289419.

Received 5 February 2007; received in revised form 15 March 2007; accepted 19 March 2007. published online 29 March 2007.

Abstract 

The aryl hydrocarbon (dioxin) receptor (AhR) has been studied for several decades largely because of its critical role in xenobiotic-induced toxicity and carcinogenesis. Albeit this is a major issue in basic and clinical research, an increasing number of investigators are turning their efforts to try to understand the physiology of the AhR under normal cellular conditions. This is an exciting area that covers cell proliferation and differentiation, endogenous mechanisms of activation, gene regulation, tumor development and cell motility and migration, among others. In this review, we will attempt to summarize the studies supporting the implication of the AhR in those endogenous cellular processes.

Abbreviations: AhR, aryl hydrocarbon (dioxin) receptor, ARNT, aryl hydrocarbon nuclear translocator, JNK, c-Jun N-terminal kinase, TGFβ, transforming growth factor β

Keywords: Aryl hydrocarbon receptor, Proliferation, Cell migration, Cytoskeleton

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 31.50 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Subscribe to this title

    Get unlimited online access to this article and all other articles in this title 24/7 for one year.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.
 

PII: S0014-5793(07)00317-1

doi:10.1016/j.febslet.2007.03.046

FEBS Letters
Volume 581, Issue 19 , Pages 3608-3615, 31 July 2007

Article Tools

* Image Usage & Resolution