FEBS Letters
Volume 581, Issue 11 , Pages 2119-2124, 22 May 2007

Spatial regulation of exocytosis and cell polarity: Yeast as a model for animal cells

Edited by Thomas Söllner

Department of Cell and Developmental Biology, University of North Carolina at Chapel Hill, 538 Taylor Hall, CB#7090, Chapel Hill, NC 27599-7090, United States

Received 19 February 2007; received in revised form 20 March 2007; accepted 21 March 2007. published online 29 March 2007.

Abstract 

Exocytosis is the major mechanism by which new membrane components are delivered to the cell surface. In most, if not all, eukaryotic cells this is also a highly spatially regulated process that is tightly coordinated with the overall polarity of a cell. The Rho/Cdc42 family of GTPases and the lethal giant larvae/Sro7 family are two highly conserved families of proteins which appear to have dual functions both in cell polarity and exocytosis. Analysis of their functions has begun to unravel the coordination between these processes and propose a model for polarized vesicle docking and fusion at the site of asymmetric cell growth.

Keywords: Rho GTPases, Lgl, Exocytosis, Cell polarity

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PII: S0014-5793(07)00318-3

doi:10.1016/j.febslet.2007.03.043

FEBS Letters
Volume 581, Issue 11 , Pages 2119-2124, 22 May 2007

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