FEBS Letters
Volume 581, Issue 15 , Pages 2862-2869, 19 June 2007

The Ndc80 complex: Hub of kinetochore activity

Edited by Giulio Superti-Furga

  • Claudio Ciferri

      Affiliations

    • Department of Experimental Oncology, European Institute of Oncology, Via Adamello 16, I-20131 Milan, Italy
    • Equal contribution.
    • Present address: Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA.
    • ,
  • Andrea Musacchio

      Affiliations

    • Department of Experimental Oncology, European Institute of Oncology, Via Adamello 16, I-20131 Milan, Italy
    • Research Unit of the Italian Institute of Technology (IIT) Foundation at the IFOM-IEO Campus, Via Adamello 16, I-20131 Milan, Italy
    • Corresponding Author InformationCorresponding author. Address: Department of Experimental Oncology, European Institute of Oncology, Via Adamello 16, I-20131 Milan, Italy. Fax: +39 02 57489851.
    • ,
  • Arsen Petrovic

      Affiliations

    • Department of Experimental Oncology, European Institute of Oncology, Via Adamello 16, I-20131 Milan, Italy
    • Equal contribution.

Received 10 April 2007; accepted 6 May 2007. published online 14 May 2007.

Abstract 

Kinetochores are protein scaffolds coordinating the process of chromosome segregation in mitosis. Kinetochore components are organized in functionally and topologically distinct domains that are designed to connect the sister chromatids to the mitotic spindle. The inner kinetochore proteins are in direct contact with the centromeric DNA, whilst the outer kinetochore proteins are responsible for binding to spindle microtubules. The conserved Ndc80 complex is implicated in several essential outer kinetochore functions, including microtubule binding and control of a safety device known as the spindle assembly checkpoint. Here, we describe how current work is contributing to unravel the complex endeavors of this essential kinetochore complex.

Keywords: Kintochore, Centromere, Cancer, Aneuploidy, Hec1, Ndc80, Nuf2, Spc24, Spc25, Spindle assembly checkpoint, Microtubule

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PII: S0014-5793(07)00536-4

doi:10.1016/j.febslet.2007.05.012

FEBS Letters
Volume 581, Issue 15 , Pages 2862-2869, 19 June 2007

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