FEBS Letters
Volume 581, Issue 15 , Pages 2757-2760, 19 June 2007

DNA photodamage recognition by RNA polymerase II

Edited by Giulio Superti-Furga

Gene Center Munich, Department of Chemistry and Biochemistry, Ludwig-Maximilians-Universität München, Feodor-Lynen-Strasse 25, D-81377 Munich, Germany

Center for integrated Protein Science CiPSM, Department of Chemistry and Biochemistry, Ludwig-Maximilians-Universität München, Feodor-Lynen-Strasse 25, D-81377 Munich, Germany

Received 5 March 2007; accepted 6 May 2007. published online 14 May 2007.

Abstract 

During gene transcription, RNA polymerase (Pol) II encounters obstacles, including lesions in the DNA template. Here, we review a recent structure–function analysis of Pol II transcribing DNA with a bulky photo-lesion in the template strand. The study provided the molecular basis for recognition of a damaged DNA by Pol II, which is the first step in transcription-coupled DNA repair (TCR). The results have general implications for damage recognition and the TCR mechanism.

Keywords: Transcription-coupled DNA repair, Multisubunit cellular RNA polymerases, Structural biology of gene transcription

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PII: S0014-5793(07)00538-8

doi:10.1016/j.febslet.2007.05.014

FEBS Letters
Volume 581, Issue 15 , Pages 2757-2760, 19 June 2007

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