FEBS Letters
Volume 581, Issue 24 , Pages 4727-4733, 2 October 2007

Mover is a novel vertebrate-specific presynaptic protein with differential distribution at subsets of CNS synapses

Edited by Jesus Avila

Institute for Anatomy and Cell Biology, University of Heidelberg, Im Neuenheimer Feld 307, D-69120 Heidelberg, Germany

Received 23 July 2007; received in revised form 7 August 2007; accepted 29 August 2007. published online 06 September 2007.

Abstract 

Presynaptic nerve terminals contain scaffolding proteins that orchestrate neurotransmitter release at active zones. Here we describe mover, a yet unknown non-transmembrane protein that is targeted to presynaptic terminals when overexpressed in cultured neurons. Confocal immunomicroscopy revealed that mover colocalizes with presynaptic markers in the calyx of Held. In the hippocampus, mover localizes to mossy fibre terminals, but is absent from inhibitory nerve terminals. By contrast, mover localizes to inhibitory terminals throughout the cerebellar cortex. Our results suggest that mover may act in concert with generally expressed scaffolding proteins in distinct sets of presynaptic terminals.

Keywords: Presynaptic, Hippocampus, Cerebellum, Calyx of Held

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PII: S0014-5793(07)00957-X

doi:10.1016/j.febslet.2007.08.070

FEBS Letters
Volume 581, Issue 24 , Pages 4727-4733, 2 October 2007

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