The lipin protein family: Dual roles in lipid biosynthesis and gene expression

Abstract 

The prevalence of obesity in the western world has focused attention on factors that influence triglyceride biosynthesis, storage, and utilization. Members of the lipin protein family have a newly discovered enzymatic role in triglyceride and phospholipid biosynthesis as a phosphatidate phosphatase, and also act as an inducible transcriptional coactivator in conjunction with peroxisome proliferator-activated receptor γ (PPARγ) coactivator-1α and PPARα. Through these activities, the founding member of the family, lipin-1, influences lipid metabolism and glucose homeostasis in diverse tissues including adipose tissue, skeletal muscle, and liver. The physiological roles of lipin-2 and lipin-3 are less well defined, but are likely to carry out similar functions in glycerolipid biosynthesis and gene expression in a distinct tissue distribution.

Abbreviations: PPARγ, peroxisome proliferator-activated receptor γ, C/EBPα, CAAT enhancer binding protein-α, N-LIP, amino-terminal lipin domain, C-LIP, carboxy-terminal lipin domain, PGC-1α, PPARγ coactivator-1α, PAP1, phosphatidate phosphatase-1, TAG, triacylglycerol, DAG, diacylglycerol, HAD, haloacid dehalogenase, DGAT, diacylglycerol acyltransferase

Keywords: Adipose tissue, Lipodystrophy, Obesity, Triaclyglycerol, Phosphatidate phosphatase, Transcriptional coactivator