FEBS Letters
Volume 582, Issue 5 , Pages 543-548, 5 March 2008

Regulation of SIRT6 protein levels by nutrient availability

Edited by Noboru Mizushima

  • Yariv Kanfi

      Affiliations

    • The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel
    • These authors contributed equally to this work.
    • ,
  • Ronnie Shalman

      Affiliations

    • The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel
    • These authors contributed equally to this work.
    • ,
  • Victoria Peshti

      Affiliations

    • The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel
    • ,
  • Shmuel N. Pilosof

      Affiliations

    • The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel
    • ,
  • Yosi M. Gozlan

      Affiliations

    • The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel
    • ,
  • Kevin J. Pearson

      Affiliations

    • Laboratory of Experimental Gerontology, NIA, NIH, Baltimore, MD 21224-6825, USA
    • ,
  • Batya Lerrer

      Affiliations

    • The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel
    • ,
  • Danesh Moazed

      Affiliations

    • Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    • ,
  • Jean-Christophe Marine

      Affiliations

    • Flanders Interuniversity Institute for Biotechnology, University of Ghent, Ghent, Belgium
    • ,
  • Rafael de Cabo

      Affiliations

    • Laboratory of Experimental Gerontology, NIA, NIH, Baltimore, MD 21224-6825, USA
    • ,
  • Haim Y. Cohen

      Affiliations

    • The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel
    • Corresponding Author InformationCorresponding author. Fax: +972 3 738 4058.

Received 5 December 2007; received in revised form 16 January 2008; accepted 17 January 2008. published online 31 January 2008.

Abstract 

Sirtuins have been shown to regulate life-span in response to nutritional availability. We show here that levels of the mammalian sirtuin, SIRT6, increased upon nutrient deprivation in cultured cells, in mice after fasting, and in rats fed a calorie-restricted diet. The increase in SIRT6 levels is due to stabilization of SIRT6 protein, and not via an increase in SIRT6 transcription. In addition, p53 positively regulates SIRT6 protein levels under standard growth conditions but has no role in the nutrient-dependent regulation of SIRT6. These observations imply that at least two sirtuins are involved in regulation of life-span by nutrient availability.

Keywords: SIRT6, Sirtuin, Calorie restriction, Nutrient availability

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PII: S0014-5793(08)00044-6

doi:10.1016/j.febslet.2008.01.019

FEBS Letters
Volume 582, Issue 5 , Pages 543-548, 5 March 2008

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