Metastasis tumor antigen 1 is involved in the resistance to heat stress-induced testicular apoptosis

Li, Wei; Bao, Wei; Ma, Jing; Liu, Xinping; Xu, Ruojun; Wang, Rui-an; Zhang, Yuanqiang

doi:10.1016/j.febslet.2008.02.013

« Previous Next »FEBS Letters
Volume 582, Issue 6 , Pages 869-873, 19 March 2008

Metastasis tumor antigen 1 is involved in the resistance to heat stress-induced testicular apoptosis

Edited by Varda Rotter

Wei Li
- Department of Histology and Embryology, The Fourth Military Medical University, Xi’an 710032, People’s Republic of China
Wei Bao
- Department of Immunology, The Fourth Military Medical University, Xi’an 710032, People’s Republic of China
Jing Ma
- Department of Histology and Embryology, The Fourth Military Medical University, Xi’an 710032, People’s Republic of China
Xinping Liu
- Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi’an 710032, People’s Republic of China
Ruojun Xu
- Department of Zoology, University of Hong Kong, Hong Kong, China
Rui-an Wang
- Department of Histology and Embryology, The Fourth Military Medical University, Xi’an 710032, People’s Republic of China
Yuanqiang Zhang
- Department of Histology and Embryology, The Fourth Military Medical University, Xi’an 710032, People’s Republic of China
- Corresponding author. Fax: +86 029 84774508.

Received 14 November 2007; received in revised form 23 January 2008; accepted 7 February 2008. published online 18 February 2008.

Abstract

Our previous study documented the expression of Mta1 during spermatogenesis. Here, we present evidence for a possible involvement of Mta1 in the regulation of testicular function, possibly by interacting with p53. A notable decrease of Mta1 expression was revealed at postsurgical day 6, consistent with the previously reported upregualtion of p53 in mouse cryptorchidism. Furthermore, in vitro over-expression of Mta1 could remarkably elevate the resistance capability of spermatogenic tumor cells against heat-induced apoptosis with a marked impairment of p53 expression. These findings indicate that Mta1 may operate as a negative modifier of apoptosis by interacting with p53 during gametogenesis.

Keywords: Human metastasis tumor antigen 1, Rat metastasis tumor antigen 1, Mouse metastasis tumor antigen 1, Nuclear remodeling and deacetylation complex, p53, Cryptorchidism, Deacetylation, Apoptosis