FEBS Letters
Volume 582, Issue 8 , Pages 1220-1224, 9 April 2008

Interaction networks for systems biology

Edited by Robert B. Russell and Patrick Aloy

EMBL, Structural and Computational Biology Unit, Meyerhofstrasse 1, D-69117 Heidelberg, Germany

Received 28 January 2008; accepted 8 February 2008. published online 18 February 2008.

Abstract 

Cellular functions are almost always the result of the coordinated action of several proteins, interacting in protein complexes, pathways or networks. Progress made in devising suitable tools for analysis of protein–protein interactions, have recently made it possible to chart interaction networks on a large-scale. The aim of this review is to provide a short overview of the most promising contributions of interaction networks to human biology, structural biology and human genetics.

Keywords: Interactome, AP–MS, Yeast two-hybrid, Protein complex, Systems biology, Protein–protein interaction

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PII: S0014-5793(08)00120-8

doi:10.1016/j.febslet.2008.02.015

FEBS Letters
Volume 582, Issue 8 , Pages 1220-1224, 9 April 2008

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