FEBS Letters
Volume 582, Issue 8 , Pages 1225-1230, 9 April 2008

Co-evolution and co-adaptation in protein networks

Edited by Robert B. Russell and Patrick Aloy

  • David Juan

      Affiliations

    • Structural Bioinformatics Group, Spanish National Cancer Research Centre (CNIO), C/Melchor Fernández Almagro 3, 28029 Madrid, Spain
    • Fax: +34 912246980.
    • ,
  • Florencio Pazos

      Affiliations

    • Computational Systems Biology Group, National Centre for Biotechnology (CNB-CSIC), C/Darwin 3, Cantoblanco, 28049 Madrid, Spain
    • Fax: +34 915854506.
    • ,
  • Alfonso Valencia

      Affiliations

    • Structural Bioinformatics Group, Spanish National Cancer Research Centre (CNIO), C/Melchor Fernández Almagro 3, 28029 Madrid, Spain
    • Corresponding Author InformationCorresponding author. Fax: +34 912246980.

Received 9 January 2008; accepted 8 February 2008. published online 18 February 2008.

Abstract 

Interacting or functionally related proteins have been repeatedly shown to have similar phylogenetic trees. Two main hypotheses have been proposed to explain this fact. One involves compensatory changes between the two protein families (co-adaptation). The other states that the tree similarity may be an indirect consequence of the involvement of the two proteins in similar cellular process, which in turn would be reflected by similar evolutionary pressure on the corresponding sequences. There are published data supporting both propositions, and currently the available information is compatible with both hypotheses being true, in an scenario in which both sets of forces are shaping the tree similarity at different levels.

Keywords: Co-evolution, Co-adaptation, Protein interaction, Mirrortree

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PII: S0014-5793(08)00122-1

doi:10.1016/j.febslet.2008.02.017

FEBS Letters
Volume 582, Issue 8 , Pages 1225-1230, 9 April 2008

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