FEBS Letters
Volume 582, Issue 6 , Pages 886-890, 19 March 2008

Interleukin-1 receptor antagonist (IL-1ra) modulates endothelial cell proliferation

Edited by Masayuki Miyasaka

Cardiovascular Research Unit, School of Medicine and Biomedical Sciences, University of Sheffield, Royal Hallamshire Hospital, Sheffield S10 2RX, United Kingdom

Received 5 December 2007; received in revised form 5 February 2008; accepted 7 February 2008. published online 18 February 2008.

Abstract 

Endothelial cell (EC) lifespan controlled by the IL-1 family of cytokines is an important determinant of susceptibility to artery wall disease. Here we show that EC lacking intracellular interleukin-1 receptor antagonist (IL-1ra) have a reduced lifespan compared to controls. Over expression of IL-1ra enhanced proliferation via cyclin dependent kinase 2 activity and retinoblastoma protein phosphorylation. This was not seen in EC lacking IL-1 receptor 1 (IL-1 signalling ability), nor apparent using other stimuli e.g. TNFα. These data suggest that IL-1ra has a specific and receptor-dependent function to control the growth and lifespan of EC.

Keywords: Endothelial cell, IL-1ra, Proliferation

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PII: S0014-5793(08)00126-9

doi:10.1016/j.febslet.2008.02.021

FEBS Letters
Volume 582, Issue 6 , Pages 886-890, 19 March 2008

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