FEBS Letters
Volume 582, Issue 14 , Pages 2004-2016, 18 June 2008

Nuclear pore complex assembly through the cell cycle: Regulation and membrane organization

Edited by Ulrike Kutay

  • Wolfram Antonin

      Affiliations

    • Friedrich Miescher Laboratory of the Max-Planck-Society, Spemannstraße 39, 72076 Tübingen, Germany
    • Corresponding Author InformationCorresponding authors. Fax: +49 7071 601801 (W. Antonin); fax: +49 6221 38798328 (J. Ellenberg).
    • ,
  • Jan Ellenberg

      Affiliations

    • European Molecular Biology Laboratory, Meyerhofstraße 1, 69117 Heidelberg, Germany
    • Corresponding Author InformationCorresponding authors. Fax: +49 7071 601801 (W. Antonin); fax: +49 6221 38798328 (J. Ellenberg).
    • ,
  • Elisa Dultz

      Affiliations

    • European Molecular Biology Laboratory, Meyerhofstraße 1, 69117 Heidelberg, Germany

Received 6 February 2008; accepted 28 February 2008. published online 06 March 2008.

Abstract 

In eukaryotes, all macromolecules traffic between the nucleus and the cytoplasm through nuclear pore complexes (NPCs), which are among the largest supramolecular assemblies in cells. Although their composition in yeast and metazoa is well characterized, understanding how NPCs are assembled and form the pore through the double membrane of the nuclear envelope and how both processes are controlled still remains a challenge. Here, we summarize what is known about the biogenesis of NPCs throughout the cell cycle with special focus on the membrane reorganization and the regulation that go along with NPC assembly.

Abbreviations: NPC, nuclear pore complex, ER, endoplasmic reticulum, MDa, Mega Dalton, ALPS, ArfGAP1 lipid packing sensor

Keywords: Nuclear pore complex, Nuclear assembly, Cell cycle, Nucleoporin

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 31.50 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Subscribe to this title

    Get unlimited online access to this article and all other articles in this title 24/7 for one year.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.
 

PII: S0014-5793(08)00190-7

doi:10.1016/j.febslet.2008.02.067

FEBS Letters
Volume 582, Issue 14 , Pages 2004-2016, 18 June 2008

Article Tools

* Image Usage & Resolution