FEBS Letters
Volume 582, Issue 14 , Pages 1987-1996, 18 June 2008

Regulation of mRNP dynamics along the export pathway

Edited by Ulrike Kutay

Department of Cell Biology, University of Geneva, 30 Quai E. Ansermet, 1211 Geneva 4, Switzerland

Received 28 February 2008; received in revised form 25 March 2008; accepted 26 March 2008. published online 02 April 2008.

Abstract 

The transcription of mRNA is tightly coupled to the concomitant recruitment of mRNA processing and export factors, resulting in the formation of mature and export competent mRNP complexes. This interconnection in gene expression implies extensive spatio-temporal control of mRNP dynamics to prevent mRNA export factors bound to pre-mRNA from functioning at the incorrect time and exporting nascent or incompletely processed pre-mRNAs. Recent discoveries provide molecular understanding of how a broad range of post-translational modifications together with RNA-dependent ATPases coordinate proteins acting at different steps and regulate mRNP assembly and export.

Keywords: mRNP dynamics, THO/TREX, Nuclear export, Ubiquitin, DEAD box ATPases, Mex67/TAP

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PII: S0014-5793(08)00285-8

doi:10.1016/j.febslet.2008.03.038

FEBS Letters
Volume 582, Issue 14 , Pages 1987-1996, 18 June 2008

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