Adiponectin promotes endothelial progenitor cell number and function

Shibata, Rei; Skurk, Carsten; Ouchi, Noriyuki; Galasso, Gennaro; Kondo, Kazuhisa; Ohashi, Taiki; Shimano, Masayuki; Kihara, Shinji; Murohara, Toyoaki; Walsh, Kenneth

doi:10.1016/j.febslet.2008.04.006

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Volume 582, Issue 11 , Pages 1607-1612, 14 May 2008

Adiponectin promotes endothelial progenitor cell number and function

Edited by Laszlo Nagy

Rei Shibata
- Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
- Molecular Cardiology, Boston University School of Medicine, Boston, MA, USA
- Corresponding authors. Address: Molecular Cardiology, Boston University School of Medicine, Boston, MA, USA. Fax: +1 617 414 2391 (K. Walsh), +81 52 744 2138 (R. Shibata).
- These authors equally contributed to the work.
Carsten Skurk
- Molecular Cardiology, Boston University School of Medicine, Boston, MA, USA
- These authors equally contributed to the work.
- Present address: Medical University of Berlin/Campus Benjamin Franklin, Berlin, Germany.
Noriyuki Ouchi
- Molecular Cardiology, Boston University School of Medicine, Boston, MA, USA
Gennaro Galasso
- Molecular Cardiology, Boston University School of Medicine, Boston, MA, USA
- Present address: University of Naples Federico II, Naples, Italy.
Kazuhisa Kondo
- Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
Taiki Ohashi
- Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
Masayuki Shimano
- Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
Shinji Kihara
- Department of Metabolic Medicine, Osaka University, Osaka, Japan
Toyoaki Murohara
- Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
Kenneth Walsh
- Molecular Cardiology, Boston University School of Medicine, Boston, MA, USA
- Corresponding authors. Address: Molecular Cardiology, Boston University School of Medicine, Boston, MA, USA. Fax: +1 617 414 2391 (K. Walsh), +81 52 744 2138 (R. Shibata).

Received 11 December 2007; received in revised form 26 March 2008; accepted 3 April 2008. published online 16 April 2008.

Abstract

Obesity-linked diseases are associated with suppressed endothelial progenitor cell (EPC) function. Adiponectin is an adipose-derived protein that is downregulated in obese and diabetic subjects. Here, we investigated the effects of adiponectin on EPCs. EPC levels did not increase in adiponectin deficient (APN-KO) in response to hindlimb ischemia. Adenovirus-mediated delivery of adiponectin increased EPC levels in both WT and APN-KO mice. Incubation of human peripheral blood mononuclear cells with adiponectin led to an increase of the number of EPCs. Adiponectin induced EPC differentiation into network structures and served as a chemoattractant in EPC migration assays. These data suggest that hypoadiponectinemia may contribute to the depression of EPC levels that are observed in patients with obesity-related cardiovascular disorders.

Keywords: Adiponectin, Angiogenesis, Endothelial progenitor cell