FEBS Letters
Volume 582, Issue 16 , Pages 2402-2406, 9 July 2008

FAK nuclear export signal sequences

Edited by Varda Rotter

  • Valeria Ossovskaya

      Affiliations

    • Department of Anatomy, University of California San Francisco, San Francisco, CA, USA
    • Current address: BiPar Sciences, Brisbane, CA, USA.
    • ,
  • Ssang-Taek Lim

      Affiliations

    • Department of Reproductive Medicine, University of California, San Diego, CA, USA
    • ,
  • Nobuyuki Ota

      Affiliations

    • A-cube Inc., Burlingame, CA, USA
    • ,
  • David D. Schlaepfer

      Affiliations

    • Department of Reproductive Medicine, University of California, San Diego, CA, USA
    • ,
  • Dusko Ilic

      Affiliations

    • A-cube Inc., Burlingame, CA, USA
    • Department of Cell and Tissue Biology, University of California San Francisco, San Francisco, CA, USA
    • Corresponding Author InformationCorresponding author. Present address: StemLifeLine Inc., 1300 Industrial Road, #13, San Carlos, CA, USA.

Received 13 April 2008; received in revised form 28 May 2008; accepted 1 June 2008. published online 10 June 2008.

Abstract 

Ubiquitously expressed focal adhesion kinase (FAK), a critical component in transducing signals from sites of cell contacts with extracellular matrix, was named after its typical localization in focal adhesions. A nuclear localization of FAK has been also reported and its scaffolding role in nucleus and requirement for p53 ubiquitination were only recently described. Whereas FAK nuclear localization signal (NLS) was found in F2 lobe of FERM domain, nuclear export signal (NES) sequences have not been yet determined. Here we demonstrate that FAK has two NES sequences, NES1 in F1 lobe of FERM domain and NES2 in kinase domain. Although, both NES1 and NES2 are evolutionary conserved, and present as well in FAK-related protein kinase Pyk2, only NES2 demonstrates full biological nuclear export activity.

Keywords: FAK, Nuclear export signal, Pyk2

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PII: S0014-5793(08)00489-4

doi:10.1016/j.febslet.2008.06.004

FEBS Letters
Volume 582, Issue 16 , Pages 2402-2406, 9 July 2008

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