FEBS Letters
Volume 582, Issue 16 , Pages 2345-2351, 9 July 2008

Spliceosomal immunophilins

Edited by Daniela Ruffell

Florida International University, Department of Biological Sciences, University Park, 11200 SW 8th Street, OE 304, Miami, FL 33199, United States

Received 14 April 2008; received in revised form 16 May 2008; accepted 2 June 2008. published online 09 June 2008.

Abstract 

The spliceosome is a dynamic, macromolecular complex, which removes non-protein-coding introns from pre-mRNA to form mature mRNA in a process known as splicing. This ribonucleoprotein assembly is comprised of five uridine-rich small nuclear RNAs (snRNAs) as well as over 300 proteins. In humans, several of the known proteinaceous splicing factors are members of the immunophilin superfamily. Immunophilins are peptidyl-prolyl cis–trans isomerases that catalyze the conversion of proteins from cis to trans at Xaa-Pro bonds. Our review of the data indicates that some members of this protein family are activators of spliceosomal proteins by way of folding and transport.

Keywords: Cyclophilin, FKBP, Spliceosome, Cyclosporin, FK506, Small nuclear RNAs

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PII: S0014-5793(08)00491-2

doi:10.1016/j.febslet.2008.06.006

FEBS Letters
Volume 582, Issue 16 , Pages 2345-2351, 9 July 2008

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