Regulation of the human tRNase Z^S gene expression

Abstract 

There are two types of tRNA 3′ processing endoribonucleases (tRNase Z): a short form (tRNase Z^S) and a long form (tRNase Z^L). Although the human genome contains both genes, little is known about the physiological role of tRNase Z^S. We found that the human tRNase Z^S gene expression appears to be post-transcriptionally regulated. Additionally, analyses for cis-regulatory elements for the tRNase Z^S gene transcription suggested that transcription factors that bind to five different sites on the promoter work together to potentiate the transcription initiation. Furthermore, we found that tRNase Z^S is predominantly present in the cytosol and hardly in the nucleus.

Abbreviations: tRNase Z^S, a short form of tRNase Z, tRNase Z^L, a long form of tRNase Z

Keywords: Promoter, Subcellular localization, Transcription, tRNase Z^S, tRNA 3′ processing