FEBS Letters
Volume 582, Issue 17 , Pages 2555-2560, 23 July 2008

Cdx2 initiates histodifferentiation of the midgut endoderm

Edited by Paul Bertone

Department of Biochemistry, Henry Wellcome Building, University of Leicester, Lancaster Road, Leicester LE1 7RH, UK

Received 7 April 2008; received in revised form 6 June 2008; accepted 16 June 2008. published online 24 June 2008.

Abstract 

Null mutation or haploinsufficiency of Cdx2 results in the development of heterotopic lesions with a gastric phenotype in the midgut endoderm. Conversely transgenic expression of Cdx2 in the stomach causes the endoderm to differentiate into intestinal-type mucosa. We demonstrate that the mesoderm adjacent to intestinal heterotopic areas expresses stomach specific Barx1 while the surrounding mesoderm is Barx1 negative. We conclude that the initiation of gut histodifferentiation lies in the endodermal expression of Cdx2 and that endodermal/mesodermal cross-talk involving Barx1 with appropriate feedback loops results in the development of the postnatal gut phenotype.

Keywords: Gut histodifferentiation, Cdx2, Barx1, Sox2

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 31.50 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Subscribe to this title

    Get unlimited online access to this article and all other articles in this title 24/7 for one year.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.
 

PII: S0014-5793(08)00523-1

doi:10.1016/j.febslet.2008.06.024

FEBS Letters
Volume 582, Issue 17 , Pages 2555-2560, 23 July 2008

Article Tools

* Image Usage & Resolution