FEBS Letters
Volume 582, Issue 17 , Pages 2496-2500, 23 July 2008

Specificity of the inhibitory effects of Dad on TGF-β family type I receptors, Thickveins, Saxophone, and Baboon in Drosophila

Edited by Lukas Huber

Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan

Received 16 April 2008; received in revised form 26 May 2008; accepted 26 May 2008. published online 24 June 2008.

Abstract 

In mammals, two inhibitory Smads (I-Smads), Smad6 and Smad7, play pivotal roles in negative regulation of TGF-β family signaling. Smad7 ubiquitously inhibits TGF-β family signaling, whereas Smad6 inhibits signaling from the ALK-3/6 subfamily in preference to that from the ALK-1/2 and ALK-4/5/7 subfamilies of TGF-β family type I receptors. In Drosophila, only one I-Smad, Dad, has been identified. Here we examined inhibitory effects of Dad on type I receptors in Drosophila. Dad inhibited Saxophone (ALK-1/2 orthologue) and Thickveins (ALK-3/6 orthologue) but not Baboon (ALK-4/5/7 orthologue). The differential modes of action of I-Smads in mammals and Drosophila are discussed.

Structured summary


MINT-6596817:

Smad7 (uniprotkb:O35253) physically interacts (MI:0218) with Sax (uniprotkb:Q7JQ39) by anti tag coimmunoprecipitation (MI:0007)

MINT-6596699:

Dad (uniprotkb:O15968) physically interacts (MI:0218) with Sax (uniprotkb:Q7JQ39) by anti tag coimmunoprecipitation (MI:0007)

MINT-6596805:

Smad7 (uniprotkb:O35253) physically interacts (MI:0218) with Thv (uniprotkb:Q95SI0) by anti tag coimmunoprecipitation (MI:0007)

MINT-6596829:

Smad7 (uniprotkb:O35253) physically interacts (MI:0218) with Babo (uniprotkb:A1Z7L9) by anti tag coimmunoprecipitation (MI:0007)

MINT-6596719:

Dad (uniprotkb:O15968) physically interacts (MI:0218) with Thv (uniprotkb:Q95SI0) by anti tag coimmunoprecipitation (MI:0007)

Keywords: TGF-β family, Smad6, Smad7, Dad, Type I receptors

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 31.50 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Subscribe to this title

    Get unlimited online access to this article and all other articles in this title 24/7 for one year.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.
 

PII: S0014-5793(08)00549-8

doi:10.1016/j.febslet.2008.05.052

FEBS Letters
Volume 582, Issue 17 , Pages 2496-2500, 23 July 2008

Article Tools

* Image Usage & Resolution