FEBS Letters
Volume 582, Issue 17 , Pages 2601-2608, 23 July 2008

The effect of MinC on FtsZ polymerization is pH dependent and can be counteracted by ZapA

Edited by Stuart Ferguson

  • Dirk-Jan Scheffers

      Affiliations

    • Corresponding Author InformationFax: +31 20 5987155.
    • Present address: Bacterial Membrane Proteomics Laboratory, Instituto de Tecnologia Química e Biológica, Avenida da República, 2781-901, Oeiras, Portugal.

Department of Molecular Microbiology, Institute of Molecular Cell Biology, VU University Amsterdam, De Boelelaan 1085, The Netherlands

Received 30 May 2008; received in revised form 16 June 2008; accepted 17 June 2008. published online 26 June 2008.

Abstract 

The min system prevents polar cell division in bacteria. Here, the biochemical characterization of the interaction of MinC and FtsZ from a Gram-positive bacterium, Bacillus subtilis, is reported. B. subtilis MinC inhibits FtsZ polymerization in a pH-dependent manner by preventing the formation of lateral associations between filaments. The inhibitory effect of MinC on FtsZ polymerization is counteracted by the presence of ZapA, a protein that promotes FtsZ filament bundling.

Keywords: Cell division, FtsZ, MinC, ZapA, GTP hydrolysis, FtsZ polymerization

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PII: S0014-5793(08)00551-6

doi:10.1016/j.febslet.2008.06.038

FEBS Letters
Volume 582, Issue 17 , Pages 2601-2608, 23 July 2008

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