FEBS Letters
Volume 582, Issue 23 , Pages 3293-3300, 15 October 2008

Collagen XVI expression is upregulated in glioblastomas and promotes tumor cell adhesion

Edited by Ned Mantei

  • Volker Senner

      Affiliations

    • Institute of Neuropathology, University Hospital Muenster, Domagkstrasse 19, D-48149 Muenster, Germany
    • Corresponding Author InformationCorresponding author. Fax: +49 251 8356971.
    • ,
  • Sabine Ratzinger

      Affiliations

    • Department of Orthopaedics, Centre of Medical Biotechnology, BioPark 1, University Hospital Regensburg, Germany
    • ,
  • Sonja Mertsch

      Affiliations

    • Institute of Neuropathology, University Hospital Muenster, Domagkstrasse 19, D-48149 Muenster, Germany
    • ,
  • Susanne Grässel

      Affiliations

    • Department of Orthopaedics, Centre of Medical Biotechnology, BioPark 1, University Hospital Regensburg, Germany
    • ,
  • Werner Paulus

      Affiliations

    • Institute of Neuropathology, University Hospital Muenster, Domagkstrasse 19, D-48149 Muenster, Germany

Received 10 July 2008; received in revised form 2 September 2008; accepted 3 September 2008. published online 17 September 2008.

Abstract 

The poor prognosis of glioblastoma patients is related to diffuse brain invasion and interaction of tumor cells with extracellular matrices (ECM). We describe expression and function of the FACIT-collagen XVI in glioblastomas. We found upregulation of collagen XVI mRNA as well as protein in glioblastomas as compared to normal cortex. SiRNA knockdown resulted in decreased cell adhesion whereas increased adhesion was observed on surfaces coated with collagen XVI. The migration of glioblastoma cells on this substrate remained unchanged. Our results demonstrate de-novo expression of collagen XVI in glioblastomas as part of the tumor specific remodeling of the ECM.

Structured summary


MINT-6743179:

Collagen IV (uniprotkb:P02462-1) and Collagen XVI (uniprotkb:Q07092) colocalize (MI:0403) by fluorescence microscopy (MI:0416)

MINT-6743170:

GFAP (uniprotkb:P14136) and Collagen XVI (uniprotkb:Q07092) colocalize (MI:0403) by fluorescence microscopy (MI:0416)

Keywords: Collagen XVI, Glioma, Glioblastoma, Adhesion

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PII: S0014-5793(08)00750-3

doi:10.1016/j.febslet.2008.09.017

FEBS Letters
Volume 582, Issue 23 , Pages 3293-3300, 15 October 2008

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