FEBS Letters
Volume 582, Issue 23 , Pages 3257-3262, 15 October 2008

The promiscuity of ARF interactions with the proteasome

Edited by Noboru Mizushima

Department of Structural and Functional Biology, University of Naples Federico II, Naples, Italy

Received 31 July 2008; received in revised form 3 September 2008; accepted 6 September 2008. published online 19 September 2008.

Abstract 

The tumor suppressor ARF is one of the most important oncogenic stress sensors in mammalian cells. Its effect is exerted through the interaction with different cellular partners, often resulting in their functional inactivation. This review focuses on the role played by the proteasome in ARF regulation of protein turnover and the function of most of its interacting partners. Specific proteasome components appear to be involved in the regulation of ARF turnover, bringing to light a complex network of interactions between ARF and the proteasome.

Keywords: p14/p19ARF, Proteasome, Cell stress sensor, REG-γ, TBP-1/PSMC3

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PII: S0014-5793(08)00761-8

doi:10.1016/j.febslet.2008.09.026

FEBS Letters
Volume 582, Issue 23 , Pages 3257-3262, 15 October 2008

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